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Last update: 06-04-2018

Adviesdiensten en Producten

PBTK-model IndusChemFate



What A computational tool for the estimation of blood and urine levels of chemicals after exposure by inhalation, oral intake and/or skin. The Physiologically Based Toxico-Kinetic (PBTK) model IndusChemFate is available as application in Microsoft Excel. See the webpage IndusChemFate on the CEFIC-LRI site.
Downloads Software application is freeware. The Excel Application  + User Manual can be are downloaded from the webpage IndusChemFate of the CEFIC-LRI site. 








Paper 1   A Generic, Cross-Chemical Predictive PBTK Model with Multiple Entry Routes Running as Application in MS Excel; Design of the Model and Comparison of Predictions with Experimental Results. Frans J. Jongeneelen; Wil F. Ten Berge. Annals of Occupational Hygiene (2011) 55: 841-864.

Paper 2   Simulation of urinary excretion of 1-hydroxypyrene in various scenarios of exposure to polycyclic aromatic hydrocarbons with a generic, cross-chemical predictive PBTK-model. Jongeneelen F, Ten Berge W.  Int Arch Occup Environ Health. (2012) 85, 689-702.

Chapter in book. Title: Interpretation of human biological monitoring data using a newly developed Physiological Based Toxicokinetic model. Frans J. Jongeneelen; Wil F. ten Berge.  Peter J. Boogaard. In: Computational toxicology, methods and applications for risk assessment. Ed B. A. Fowler, Elsevier Inc. (2013) ISBN: 978-0-12-396461-8. Chapter 8, pp 137-149.

Demonstration video    See on YouTube
Product presentations Hand-outs of our presentations at various scientific meetings