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| last update: | 05-04-2012 | |
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Adviesdiensten en Producten PBTK-model IndusChemFate |
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Item |
Information |
| What and where? | A computational tool for the estimation of blood and urine levels of chemicals after exposure by inhalation, oral intake and/or skin. The Physiologically Based Toxico-Kinetic (PBTK) model IndusChemFate is available as application in Microsoft Excel. See more at the webpage IndusChemFate at the CEFIC-LRI site. |
| Downloads | Software
application is freeware. The Excel
application IndusChemFate and the User Manual are downloadable from the webpage induschemfate
of the CEFIC-LRI site.
Two version are available 1.6 (2010) and 2.0 (Version 2.0 holds extended human phsiology of males, females, normal or obese and children and phsiology of expermental rats and mice) |
| Papers | Paper
1 A Generic, Cross-Chemical Predictive PBTK Model with Multiple
Entry Routes Running as Application in MS Excel; Design of the Model
and Comparison of Predictions with Experimental Results. Frans J.
Jongeneelen; Wil F. Ten Berge.
Annals of Occupational Hygiene 2011 55: 841-864
Paper 2 Simulation of urinary excretion of 1-hydroxypyrene in various scenarios of exposure to polycyclic aromatic hydrocarbons with a generic, cross-chemical predictive PBTK-model. Jongeneelen F, Ten Berge W. Int Arch Occup Environ Health. 2011 Oct 29. Epub ahead of print. |
| Demonstration video | See on YouTube |
| Product presentations | Hand-outs of presentations at various expert meetings |
| Developed by | Wil ten Berge (Santoxar) & Frans Jongeneelen (IndusTox Consult) |