A computational tool for the estimation of blood and
urine levels of chemicals after exposure by inhalation, oral intake and/or skin.
The Physiologically Based Toxico-Kinetic (PBTK) model IndusChemFate is available as
application in Microsoft
Excel. See more at the webpage IndusChemFate at the CEFIC-LRI
application is freeware. The Excel
application IndusChemFate and the User Manual are downloadable from the webpage induschemfate
of the CEFIC-LRI site.
Two version are available 1.6 (2010)
and 2.0 (Version 2.0 holds extended
human phsiology of males, females, normal or obese and children and
phsiology of expermental rats and mice)
1 A Generic, Cross-Chemical Predictive PBTK Model with Multiple
Entry Routes Running as Application in MS Excel; Design of the Model
and Comparison of Predictions with Experimental Results. Frans J.
Jongeneelen; Wil F. Ten Berge.
Annals of Occupational Hygiene 2011 55: 841-864
Simulation of urinary excretion of 1-hydroxypyrene in various scenarios of
exposure to polycyclic aromatic hydrocarbons with a generic, cross-chemical
predictive PBTK-model. Jongeneelen F, Ten Berge W. Int Arch Occup Environ Health. 2011 Oct 29.
Epub ahead of print.
||See on YouTube
presentations at various expert meetings
ten Berge (Santoxar) & Frans
Jongeneelen (IndusTox Consult)